SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '65ee8c0a2cce41ec39d7339173f2ea129f1d046e065588d961d354f4a97285ba' 
  AND token = 'YkcmvrG2Mgg7VYNTPsQtUxEbs3h6CA/H5YRjUzLbgzE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}