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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '27eaf852790621635214d855d3cb601ce2e33c85edfe725e8448a51c7ad77683' 
  AND token = '73Nz9b+UYsDIV8ryKbGFXTTd7ZVdiSrvUSArTvZ5wR4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}