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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '7a80abc89ee148571a451b67ebc1e77cf8741eff6ccec794b29e880ff4ff7d77' 
  AND token = 'IsOTON0ljn8YgC0QfZgzuV0NvrvkSwB/CXvWRTwvhpc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00013

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}