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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '49551468b7357060f033d8426da19e3dae1cee87c9974bdc06d28708908f348b' 
  AND token = '4IR0kT8PMuWLugbejPitVopY0DZTi1RSuMianS7MAvk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00030

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}