SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0b487fbbe1101824d39db9ea1b506f0018177a0f65b97347b3f9447e21e1726a' 
  AND token = 'yLcRTrqA2aGDytzEt5dJ5oRpwwLi3gmEBLlzXnjPAHA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00014

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}