SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0004529db6903c9b88e9601781a62e9adf3009c83e216cf1117b71203df6649c' 
  AND token = 'NeaMXTBPsI0kcDn/chxlMRz5YPtynAm1lASJG7RGiZ0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}