SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2b1e4a50b23380dd26ad22205f3a3d03c576856c5e59e180dc15314077961b29' 
  AND token = 'dj7s0Br30b1qgBdYy6W3h9O4hFiQEZk0rfZZEQoM48A=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}