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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6eb9588fa229093e8a0a3655935141472ade80c4c04a2a20c02097440adce783' 
  AND token = '49MEctr8xnObvf4LfzVyZod1gW2V21yYmj+qyK/kEKs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00045

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}