SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '280d64d204dcf1f761f535015a8bfd50a3c018eabe48642254ca5000f931d74a' 
  AND token = 'lj0ZKUayg87tqIvdu5jvBDyhlgACNyhgxqqtZhz/uR8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}