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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '46a0bead46d2421fcddde6772d5bf77e20e8a4f650a57be2790f6454d96c8723' 
  AND token = 'HfrMR/jnev8MP6NRuyP3NkgldB++itmAVt7o/d2cUQ8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}