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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '22e00665705a8eec6d9c46a7b5aff3305506febf12293b0a011a67978bbd8f48' 
  AND token = 'kV2DMs5i16f5bJpKJSCF7QZwvyMmvFWj+dfzDs4OFic=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00033

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}