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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e97925c60efc6d898f085572c5402c42404f6bb608dc50a2dcc4681435cf965c' 
  AND token = 'JQI6+k0KjLW96TKo5K8UIN2n1EqqNuV4nf7d1yY1KDM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}