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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ef65a685bb11c0058a1aeaf9039d0c9b9ed05e46908fd425e2b33b47779a4d20' 
  AND token = 'uU/qJMT004OKwcTJ+M/l69HpqDVOHMrliaw81iG1Uq8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}