SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e80586ef5e465390409d3de2a9043efe35b6ecd80e484930e991ef2675550759' 
  AND token = 'hkeEX7v/SfkA0FDA3TuQaxXxeqFXBkFiQX0YaEWz/sY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00035

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}