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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c43e6fdaac037a305d9da8dc7c0c01c005e67118f604b0dbfff32b981ec3dca1' 
  AND token = 'NnYaoRFlha4FciI47dAVeJDsGpMfAX5kolAj7IDd/cE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}