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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '222fb6ed6f1fa1fd477adc0e18eab9a12a429c90e43deadbf77ddb3fed37a575' 
  AND token = 'ek8yrE9dfGbM9Jm3S3Zxm95UUX0LyFZfudArQHrhmXA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}