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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4d9d49177cbb963fee342519f4e02e448db7a57f642f9b1e348593316e4dd1da' 
  AND token = 'cHydkl0lAG2pWu2wFsv5KzBgb2GMC07VlyTa3qEDn+0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00017

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}