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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1d43840866776db901d056ec496623bd50c9f4b02e0eb78e32bc5fb05b578300' 
  AND token = 'k/hmG638TvoZQ8djAUWrA3A7hp34vKV49bAZI/ASwyE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00044

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}