SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '488e8f4830b017734c5a450e0b1eba929795ba561e079b0e8b8166aa3d5b8268' 
  AND token = 'NrFkh3ns4fVrN0rnAWphLTXcZ8INXdaUa2BbwvqY3Rs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}