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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '561e57f38c265464648393f4be21bb6a960d382a1e46f531507df1b5a89d41f8' 
  AND token = 'c6bgruM6bjdeyTB0IIR9/p/1SulUsd9DWlw1XMAgBzk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}