SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5cd78357fe0eb62eb393d918337d4888504e31101d02322448074427f49bf751' 
  AND token = 'eAI+s6UtkxhuYaaEQ+WoDUXFOlKcDKsnNUFR53d3eHw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}