SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e357ab2746fb6fc388bb1734f431a24059453e3b796c7f264037516f9bee0521' 
  AND token = '+n4lbyowglK7EHMWR48JWPrQosB56NIk98kLqTUj43g=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00029

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}