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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4274341686e2cdbd7449025b1f3cfd966f15b375af527496797faf5a853bf3cf' 
  AND token = 'G2xBMx2xWNWRk+WW5XKj0wgwuSn0X/d08LsR7UReSdk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}