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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2263c0eda17aedf31002faec6b4c0d314169967cfba3b72d416a4871b67b65a2' 
  AND token = 'zIPYXUWBk+khpUeBC6q1Z1kM/wWMDpzlsOXO2TqwIkM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00036

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}