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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '486952c0dd8023e5ed15c33024df36dd9db6fcf2c7eff443467c2adb741507ec' 
  AND token = 'C75R09FhV8uJYFf8JE1tTfhcKzTDYclNogPHYJvdfAU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00057

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}