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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5037857f3c06a1ce562e9997f42bce66810ff5b3cc30b63c955df9270df26d35' 
  AND token = 'f2vhWoJaOBSR3oF3x+SXsLDkJuBejbk+EbkgYeCkZfg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}