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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '45a3c3b5020344cadf7b37c15175918432063733a7c33131bc426a5dc2e4c03a' 
  AND token = '7i2USpwUs6/yGf4JaoznwN+chRRWsDIdDquvfWvHfE4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}