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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1ae721da06e2c9e266c97abb818d919c32c3067ac36ff4ee59e90338d3a0b896' 
  AND token = 'zxGOfMyxXhcpth9aEeeEMYd3/apdYHGVTGKRtlLv6UE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}