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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'da1249cbdc2ef1745be18e8c604ac65d132e4c618d49c514292f09b2c71c6010' 
  AND token = 'E6DGymct48xFiiQfg3C0NeUn56T6tVZ1E0/PZoWKZ6I=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}