SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5cf1edec21fd3abe0162deadf0b825ad18ad82c699d5977054c6384dbf8f4645' 
  AND token = 'E6A1MxJRRNQzvpaaBPlzvQAIvwoPKVnrMluMtEvR7+E=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}