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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'dd3428d50b8de9485be7777cc3093369b3d37f80752132d50f65ef521a2c360a' 
  AND token = 'i44DtU9UCN6Bik/7kn1+2fQkhfcdDMOXwObJt0j8aTo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}