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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a9226228d05404c66bea4c656f42599553a282a2d638a952499298549418411c' 
  AND token = '4xXwRJSejhaPcv0358jnSveZCt02P5eokqXC2dXjLpo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}