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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '621cc71993c65b6f06f5edc885a272497eb42b79287429c7fc1200a536255e51' 
  AND token = 'mIZwedXF68xeCXaCQFJ/5ww25YgCKrrms6cJBkoFdAw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}