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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '111600154f2a806d8aae643776f4b88ef6d1209719bf6be07f055851bd8eefea' 
  AND token = 'PQvAgo/Dl1AHUVpLv5FwvEwf/Ufehry7L9XMggBJCro=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}