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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '378b9708ed1d2378138c33b17f579c62d0963900604d7bf22ac2c7c362630f28' 
  AND token = 'emST85XT5QTe4XMz29KG6JbGEHAM+0c0pb+gj/jYa/w=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00044

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}