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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c95fdd030e2fab718549c1e1882dbe110a9d762bc0d8bf158ab367b623c69735' 
  AND token = 'G+xRRHUZQsN7OaRCADfSNVewX1L18aYsnOaWlTnXrAQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}