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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '34d2605302906248a3142847063a93c23ca6b635da31267189a649e5146c910f' 
  AND token = 'SrPWxe9DldcNM5cEH+VxTLfLJikNvZJ6TeCMmzmkbPs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}