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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '888bc8636dbc45e3457a9a0bdf2d46ab1910ea302c21cfc652a74e187f4a2d34' 
  AND token = 'CqodrUbzUZV9rd0Q4QMW7Dbzw3IgTVz3zG/HVuWctFA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}