SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '21cf36523cfbaba56442645e760a62ce6d735e95448dd6fdb4076c398c515428' 
  AND token = 'icqxkOrb8cQ3W9znFzQSUjic545vE0f9wfo1KSZHHng=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}