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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e39581a1b0d837421db5006f72bd0d3d262f13fa76ffcd3f102f5d022bf7a20c' 
  AND token = 'UGvLUOC9uGEt6DAYTiqDpTnB2+mVy7XhbXcpQZhSYM0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00032

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}