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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '65bab78113a1be0166d76095cd811e9e67ddf532afaef4470f4a69f2e0ee2428' 
  AND token = 'EZAlDkk6GSIZBX5awLIA4hj/icpdGWBdwidAbiDrWW4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}