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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '43ddda43f7f2be47c3cfc9ae72d879a84379362504c733201a4b165723996fa7' 
  AND token = 'p1flFWUkWU36Pfo6z/xF3UY1HfhyzkQRuJTXZyD+Zw0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00036

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}