SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '727b1333daa0491165811d0aa5508ab6fb62ad1d327ca4a3cf44a69ac3d35cc8' 
  AND token = 'LzNWxXtir3eZWI2pDLJIJuhvAoPJJhucSjzKbndZ/8I=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00031

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}