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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '25df9c3bbe26c53c7a7add5f57e91cfaf371a7d32d1a6726b76cb379f8d66262' 
  AND token = 'p0xFry1WwFoRtLbLoDf/UTej/kSL/JaZHRzbviEw5J8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00033

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}