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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'fc721c63d0b19c183a52b8e3ad72a6a03989810b259a1927af7efff10e17b456' 
  AND token = 'nLrFOXl+8TE0TRtX7gdVFQhHG5iEsZgdvba+msZbs/s=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}