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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '16fb9815ea4116b1d7785ff0bfbfce037d323f6e80938c14a7d91f9a7d779438' 
  AND token = 'zadlC/Cc9dYaDS6LPf3Gmj1XwuSFnsnR+9LsFk11sB0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}