SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4cd3f40f461d1b0f0eef595adb947a2a79bade587e5debfbcb1b0beb10ba08ba' 
  AND token = 'veLeu21YDalaYoRu/66amlL1zrJNSwc/B405DRPszlA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}