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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '9278b4af607b75d8346791e92d490c8887b31e3a1328c8fbce229211726fbb11' 
  AND token = 'IWj5VH+jdk7kVuFMbp8Bo3iWfZd+7JFHcTVHQIn8Ly4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}