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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'fdd159340fa29502fe48e659ee07a1b3a344d3e075c795748f272a088fbd660c' 
  AND token = 'UcbqKP+8HRklNvBm1izeZQ+qtTK9msBJ0cr9VxzRiNE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}