SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '22e22af03808bf9761477172f688628221580e381628bf7b9b38de23578c1c70' 
  AND token = 'SiKmOvxLIxpfWTiXhPgeOJQlZvFOEJ5u8D5G+lVj14g=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00014

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}